Long-term inflammation and changes associated with venous disease can cause persistent pigmentation.
One contributor is the breakdown of red blood cells that can occur when blood vessels are under increased pressure. Iron-containing pigments can accumulate in the skin, producing a brownish or reddish-brown appearance.
Chronic inflammation can also trigger changes in skin pigmentation.
In people with darker skin tones, inflammation may cause particularly noticeable brown, purple, or gray discoloration. More generally, inflammatory skin conditions can cause post-
